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Vol. 11, Issue 8, 2631-2642, August 2000
School of Biochemistry and Genetics, The Medical School, University
of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
A genetic screen was performed in Saccharomyces
cerevisiae to identify mechanisms important for the
transcriptional activation of genes encoding antioxidant proteins.
Thioredoxin peroxidase, Tsa1p, of the thioredoxin system, was found to
be essential for the transcriptional induction of other components of
the thioredoxin system, TRX2 (thioredoxin) and
TRR1 (thioredoxin reductase), in response to
H2O2. The expression of TRX2 and
TRR1 is known to be regulated by the transcription
factors Yap1p and Skn7p in response to H2O2,
and the Tsa1p-dependent regulation of TRX2 requires the Yap1p/Skn7p pathway. The data suggest that expression of components of
the thioredoxin system is dependent on the activity of Tsa1p in
response to H2O2 in a Yap1p/Skn7p-dependent pathway.
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